Pharmaceutical Chemicals Abemaciclib for Anti-Cancer CAS 1231929-97-7

• Customization: Available
• CAS No.: 1231929-97-7
• Formula: C27h32f2n8
• Model NO.: 1231929-97-7
• EINECS: /
• Grade: /
• Function: /
• Usage: Cosmetic Raw Materials
• Raw Material: /
• Transport Machine: Ordinary Goods Truck
• Density: N/a
• Boiling Point: 689.3±65.0 °c at 760 Mmhg
• Flash Point: 370.7±34.3 °c
• Melting Point: N/a
• Transport Package: Drum
• Specification: 99%
• Trademark: Labeyod
• Origin: China

Product Description

Product Description

 
Function of Abemaciclib

Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers.

Abemaciclib is a CD4/6 kinase inhibitor. This type of kinase is activated by connecting D-cyclin. In breast cancer cell lines that are estrogen receptor positive (HR+), cyclin D1 and CD4/ 6 It can bind to phosphorylation of retinoblastoma protein (Rb), cell cycle progression and cell proliferation. In vitro, continuous exposure to Abemaciclib inhibits Rb phosphorylation and prevents entry from G1 into the S phase of the cell cycle, leading to cell senescence and apoptosis. In breast cancer xenotransplantation models, Abemaciclib monotherapy or combined with anti-estrogens can be administered continuously every day to shrink tumors.
 

Product Name	Abemaciclib Powder
Appearance	white powder
CAS	1231929-97-7
Assay	99%
Keywords	Abemaciclib;Abemaciclib Powder;Abemaciclib CAS 1231929-97-7
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

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